Endocrine Abstracts

Hypothalamic–pituitary–adrenal (HPA) axis function after trans-sphenoidal pituitary surgery is commonly assessed using post-operative morning cortisol. We performed a prospective study to determine the sensitivity and specificity of cortisol and ACTH measured within the first 24 h, in predicting glucocorticoid requirement at 6 months both in patients with pre-operative secondary adrenal insufficiency (SAI) and with normal pituitary function. Exclusion criteria includ...

Hypertonic saline stimulated copeptin measurements have recently been described for the diagnosis of central DI. A copeptin cut-off of > 4.9 pmol/l has a diagnostic accuracy of 96.5% for distinguishing primary polydipsia from central DI1. A copeptin assay has recently been established in our laboratory. Validation of hypertonic saline-stimulated copeptin concentrations in our local population is needed before this test can be used with confidence in patients pre...